Medicine for Irritability: Natural & Pharmaceutical

By Noelina R. | Updated: Jun 18, 2020


When irritability becomes a daily struggle for women, they may begin to search high and low for irritability medicines that will bring them long-lasting results. Continue reading to learn about some of the best natural and pharmaceutical medicine for irritability during menopause so you can finally have emotional stability.

medicine for irritability

Natural Medicine for Irritability

Vitamins and Minerals


Vitamins B and C are renowned for helping support the adrenal glands, which will help calm irritability caused by adrenal fatigue.

Also, magnesium is a natural sedative used as irritability medicine since the mineral helps calm the brain from stress.


Phytoestrogenic herbal supplements - like black cohosh and the adaptogenic herbs ashwagandha and ginseng - have been recommended by herbalists for years when it comes to treating irritability and mood swings during menopause.

They work by providing the body with plant-based estrogens, which fill the hormonal gap present as production from the ovaries wanes. However, their long-term use can cause the body to create less of its own hormones.

Nevertheless, a more effective herb used as natural medicine for irritability and anger is maca, present in hormone-regulating supplements like Macafem, which levels bodily hormones to lessen symptoms. 

Maca nourishes the pituitary and endocrine glands to produce their own hormones, thus relinquishing the need for the introduction of exogenous ones. As such, it is considered safer for long-term use.

Pharmaceutical Medicine for Irritability



Though generally prescribed to treat insomnia, loss of appetite, and fatigue associated with depression, antidepressants such as paroxetine and venlafaxine are also prescribed as medicine for irritability.

However, antidepressants can also worsen irritability. So, it is important to monitor its effects on mood soon after beginning its treatment regimen for possible adjustment.

Hormone Replacement Therapy (HRT)

For menopausal women, HRT in the form of estrogen, progesterone, or combined may be prescribed as irritability medicine as well as to treat other symptoms of hormonal imbalance, such as mood swings, hot flashes, night sweats, and low libido, among others.

Use HRT with caution as its long-term use has proven to increase the risk of developing serious health conditions, such as breast or endometrial cancer, heart disease, and more.


When looking for a well-rounded treatment plan for menopausal irritability, it is not enough to only incorporate aforementioned pharmaceutical or natural medicines into your life. Effective irritability treatments focuses on instilling lifestyle changes and wholesome habits into your daily routine as well, thus encompassing all aspects of one's holistic health. With these tools at your fingertips, you will be on your way to stable mental health in no time.

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